Spatial risk profiling of Schistosoma japonicum in Eryuan county, Yunnan province, China

  • Peter Steinmann Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland.
  • Xiao-Nong Zhou National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China.
  • Barbara Matthys Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland.
  • Yuan-Lin Li Institute of Research and Control of Schistosomiasis in Dali Prefecture, Dali Xiaguan, China.
  • Hong-Jun Li Eryuan County Schistosomiasis Control Station, Eryuan, China.
  • Shao-Rong Chen Institute of Research and Control of Schistosomiasis in Dali Prefecture, Dali Xiaguan, China.
  • Zhong Yang Institute of Research and Control of Schistosomiasis in Dali Prefecture, Dali Xiaguan, China.
  • Weng Fan Institute of Research and Control of Schistosomiasis in Dali Prefecture, Dali Xiaguan, China.
  • Tie-Wu Jia National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China.
  • Lan-Hua Li National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China.
  • Penelope Vounatsou Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland.
  • Jürg Utzinger | juerg.utzinger@unibas.ch Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland.

Abstract

Bayesian spatial risk profiling holds promise to enhance our understanding of the epidemiology of parasitic diseases, and to target interventions in a cost-effective manner. Here, we present findings from a study using Bayesian variogram models to map and predict the seroprevalence of Schistosoma japonicum in Eryuan county, Yunnan province, China, including risk factor analysis. Questionnaire and serological data were obtained through a cross-sectional survey carried out in 35 randomly selected villages with 3,220 people enrolled. Remotely-sensed environmental data were derived from publicly available databases. Bivariate and non-spatial Bayesian multiple logistic regression models were used to identify associations between the local seroprevalence and demographic (i.e. age and sex), environmental (i.e. location of village, altitude, slope, land surface temperature and normalized difference vegetation index) and socio-economic factors. In the spatially-explicit Bayesian model, S. japonicum seroprevalence was significantly associated with sex, age and the location of the village. Males, those aged below 10 years and inhabitants of villages situated on steep slopes (inclination ≥20°) or on less precipitous slopes of >5° above 2,150 m were at lower risk of seroconversion than their respective counterparts. Our final prediction model revealed an elevated risk for seroconversion in the plains of the eastern parts of Eryuan county. In conclusion, the prediction map can be utilized for spatial targeting of schistosomiasis control interventions in Eryuan county. Moreover, S. japonicum seroprevalence studies might offer a convenient means to assess the infection pressure experienced by local communities, and to improve risk profiling in areas where the prevalence and infection intensities have come down following repeated rounds of praziquantel administration.

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Published
2007-11-01
Section
Original Articles
Keywords:
Schistosoma japonicum, seroprevalence, risk mapping and prediction, Bayesian variogram models, geographical information system, remote sensing, China.
Statistics
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How to Cite
Steinmann, P., Zhou, X.-N., Matthys, B., Li, Y.-L., Li, H.-J., Chen, S.-R., Yang, Z., Fan, W., Jia, T.-W., Li, L.-H., Vounatsou, P., & Utzinger, J. (2007). Spatial risk profiling of Schistosoma japonicum in Eryuan county, Yunnan province, China. Geospatial Health, 2(1), 59-73. https://doi.org/10.4081/gh.2007.255

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