https://doi.org/10.4081/gh.2023.1197
The spatial distribution of interleukin-4 (IL-4) reference values in China based on a back propagation (BP) neural network
Submitted: 23 March 2023
Accepted: 27 August 2023
Published: 13 September 2023
Accepted: 27 August 2023
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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This study aimed to investigate the geospatial distribution of normal reference values of Interleukin 4 (IL-4) in healthy Chinese adults and to provide a basis for the development of standard references. IL-4 values of 5,221 healthy adults from 64 cities in China were collected and analyzed for a potential correlation with 24 topographical, climatic and soil factors. Seven of these factors were extracted and used to build a back propagation (BP) neural network model that was used to predict IL-4 reference values in healthy individuals from 2,317 observation sites nationwide. The predicted values were tested for normality and geographic distribution by analytic Kriging interpolation to map the geographic distribution of IL-4 reference values in healthy Chinese subjects. The results showed that IL-4 values generally decreased and then increased from the South to the North. We concluded that the BP neural network model applies to this approach, where certain geographical factors determine levels of various biochemical and immunological standards in healthy adults in regions with different topography, climate and soil indices.
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How to Cite
Huang, Z. R., Ge, M., Pang, X. R., Song, P., & Wang, C. . (2023). The spatial distribution of interleukin-4 (IL-4) reference values in China based on a back propagation (BP) neural network. Geospatial Health, 18(2). https://doi.org/10.4081/gh.2023.1197
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