Bayesian spatial modelling and the significance of agricultural land use to scrub typhus infection in Taiwan

Nicola A. Wardrop, Chi-Chien Kuo, Hsi-Chieh Wang, Archie C. A. Clements, Pei-Fen Lee, Peter M. Atkinson
  • Chi-Chien Kuo
    Geography and Environment, University of Southampton, Hampshire, United Kingdom
  • Hsi-Chieh Wang
    Research and Diagnostic Centre, Centres for Disease Control, Department of Health, Taipei, Taiwan, Province of China
  • Archie C. A. Clements
    School of Population Health, University of Queensland, Brisbane, Australia
  • Pei-Fen Lee
    Institute of Ecology and Evolutionary Biology, National Taiwan University, Taipei, Taiwan, Province of China
  • Peter M. Atkinson
    Geography and Environment, University of Southampton, Hampshire, United Kingdom

Abstract

Scrub typhus is transmitted by the larval stage of trombiculid mites. Environmental factors, including land cover and land use, are known to influence breeding and survival of trombiculid mites and, thus, also the spatial heterogeneity of scrub typhus risk. Here, a spatially autoregressive modelling framework was applied to scrub typhus incidence data from Taiwan, covering the period 2003 to 2011, to provide increased understanding of the spatial pattern of scrub typhus risk and the environmental and socioeconomic factors contributing to this pattern. A clear spatial pattern in scrub typhus incidence was observed within Taiwan, and incidence was found to be significantly correlated with several land cover classes, temperature, elevation, normalized difference vegetation index, rainfall, population density, average income and the proportion of the population that work in agriculture. The final multivariate regression model included statistically significant correlations between scrub typhus incidence and average income (negatively correlated), the proportion of land that contained mosaics of cropland and vegetation (positively correlated) and elevation (positively correlated). These results highlight the importance of land cover on scrub typhus incidence: mosaics of cropland and vegetation represent a transitional land cover type which can provide favourable habitats for rodents and, therefore, trombiculid mites. In Taiwan, these transitional land cover areas tend to occur in less populated and mountainous areas, following the frontier establishment and subsequent partial abandonment of agricultural cultivation, due to demographic and socioeconomic changes. Future land use policy decision-making should ensure that potential public health outcomes, such as modified risk of scrub typhus, are considered.

Keywords

scrub typhus, spatial epidemiology, conditionally autoregressive model, disease ecology, Orientia tsutsugamushi, Taiwan.

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Submitted: 2014-12-15 10:18:07
Published: 2013-11-01 00:00:00
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Copyright (c) 2013 Nicola A. Wardrop, Chi-Chien Kuo, Hsi-Chieh Wang, Archie C. A. Clements, Pei-Fen Lee, Peter M. Atkinson

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