Environmental determinants of Opisthorchis viverrini prevalence in northeast Thailand

Yi-Chen Wang, Chen-Chieh Feng, Paiboon Sithithaworn
  • Yi-Chen Wang
    Department of Geography, National University of Singapore, Singapore, Singapore | geowyc@nus.edu.sg
  • Chen-Chieh Feng
    Department of Geography, National University of Singapore, Singapore, Singapore
  • Paiboon Sithithaworn
    Department of Parasitology, Khon Kaen University, Khon Kaen, Thailand


Opisthorchis viverrini infection is an important, human, parasitic disease along the middle and lower Mekong River of Southeast Asia. Despite vast efforts in epidemiological research, the wide geographical variation in O. viverrini prevalence remains unexplained. To investigate the potential influence of village location, prevalence data recorded during the year 2009 for 90 villages in northeast Thailand were analysed by a geographical information systems approach based on a digital elevation model for altitude determination. Land use compositions of village surroundings were derived from images produced by the Thematic Mapper of the Landsat satellite and landscape metrics were applied to quantify spatial patterns. Pearson’s correlation coefficients were used to evaluate the associations between the environmental factors and O. viverrini prevalence. In spite of no statistical difference (P = 0.117), higher-ground villages generally had a lower level of opisthorchiasis than those situated lower down, while a significant negative correlation was detected between O. viverrini prevalence and the composition of farmland with low water content (P = 0.028), indicating the potential influence of agricultural lands with drought-tolerant crops. Strengthening this hypothesis, a significant positive association with O. viverrini prevalence was found for the combined land use classes of water and of farmland with high water content (P = 0.032), indicating that the dominance of a large land use patch capable of providing suitable habitats for the intermediate hosts might contribute to the disease. This study highlights the influence of landscapes on the epidemiology of O. viverrini infection and emphasises the need to incorporate land use planning into control strategies.


spatial epidemiology, Opisthorchis viverrini, food-borne trematodiasis, neglected tropical disease, land use, geographical information systems, Thailand.

Full Text:

Submitted: 2014-12-11 16:36:30
Published: 2013-11-01 00:00:00
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:


Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Copyright (c) 2013 Yi-Chen Wang, Chen-Chieh Feng, Paiboon Sithithaworn

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
© PAGEPress 2008-2018     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185